Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide stucture for the activity

DOI: 10.1021/jm00130a011

Source and publish data:

Journal of Medicinal Chemistry p. 2292 - 2296 (1989)

Update date:2022-08-02

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Authors:

Kagechika

Himi Himi

Kawachi Kawachi

Shudo Shudo

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Article abstract of DOI:10.1021/jm00130a011

N-Methylation of two retinoidal amide compounds, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid (3, Am80) and 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2- naphthalenyl)carbonyl]amino]benzoic acid (5, AM580), resulted in

Full text of DOI:10.1021/jm00130a011

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