Tetrahedron Letters p. 4891 - 4894 (1996)
Update date:2022-08-05
Topics:
Neel, David A.
Holmes, Richard E.
Paschal, Jonathan W.
The synthesis of bicyclic pyrazolidinone 2 is described. Traditional methods for penem and cephem ring cyclization were found to be unsuccessful and new methodology using a Curtius rearrangement was utilized. The 3- enamine 11 was hydrolysed to the desired β-keto ester 2b without substantial loss of the t-BOC protecting group.
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Doi:10.1007/BF00471248
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