A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin

Article abstract of DOI:10.1016/j.tet.2015.08.012

The allylation of indirubin produced the expected indolic N′-allylindirubin and N,N′-diallylindirubin derivatives in moderate yields, together with the corresponding N-substituted isatin products. At higher temperatures, the base-initiated reaction with a