Synthesis of O-(α-Aminoacyl)glycolic and -lactic Amides from 2-Bromoacetamides or -propanamides with N-Protected Amino Acids

Article abstract of DOI:10.1055/s-1988-27761

2-Bromocarboxamides carrying a primary, secondary or tertiary halide and a primary or secondary amide function react with N-protected amino acids in the presence of silver oxide to afford the desired depsipeptide analogs in high yields.Some racemization w