Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern

DOI: 10.1016/j.bmcl.2010.03.068

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2770 - 2775 (2010)

Update date:2022-09-26

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Authors:

Lange, Jos H.M.

van der Neut, Martina A.W.

Borst, Alice J.M.

Yildirim, Mahmut

van Stuivenberg, Herman H.

van Vliet, Bernard J.

Kruse, Chris G.

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Article abstract of DOI:10.1016/j.bmcl.2010.03.068

The cannabinoid CB₁/CB₂ receptor subtype selectivity in the 1,2-diarylimidazole-4-carboxamide series was boosted by fine-tuning its 5-substitution pattern. The presence of the 5-methylsulfonyl group in 11 led to a greater than ～840-f

Full text of DOI:10.1016/j.bmcl.2010.03.068

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