Methylenephenylsulfone appended acetals and ketals: New class of carbonyl protective groups cleavable by DBU

Article abstract of DOI:10.1016/S0040-4039(98)00209-3

3-phenylsulfonyl 1,2 propane diol, readily obtainable by dihydroxylation of commercially available allylphenylsulfone, acts as an efficient and new protection reagent for both aldehydes and ketones. This protective group is elegantly removed by use of 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), under nonaqueous conditions.