The Reformatsky Type Reaction of Gilman and Speeter in the Preparation of Valuable β-Lactams in Carbapenem Synthesis: Scope and Synthetic Utility

DOI: 10.1021/jo00285a021

Source and publish data:

Journal of Organic Chemistry p. 5736 - 5745 (1989)

Update date:2022-07-30

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Authors:

Palomo, Claudio

Cossio, Fernando P.

Arrieta, Ana

Odriozola, Jose M.

Oiarbide, Mikel

Ontoria, Jesus M.

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Article abstract of DOI:10.1021/jo00285a021

The preparation of apppropriately substituted 3-alkyl β-lactams from the Reformatsky type reaction of Gilman and Speeter is described.Treatment of Schiff bases derived from α-methylcinnamaldehyde and amines with ethyl α-bromobutyrate or ethyl α-bromoisova

Full text of DOI:10.1021/jo00285a021

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