SYNTHESES OF CHIRAL OXAZOLOTETRAHYDROISOQUINOLINE AND ITS ASYMMETRIC ALKYLATION. SYNTHESIS OF (S)-(-)- AND (R)-(+)-SALSOLIDINES

DOI: 10.1016/S0040-4039(00)88483-X

Source and publish data:

Tetrahedron Letters p. 6949 - 6950 (1988)

Update date:2022-07-30

Topics:

Authors:

Yamato, Masatoshi

Hashigaki, Kuniko

Ishikawa, Shigetaka

Qais, Nazmul

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Article abstract of DOI:10.1016/S0040-4039(00)88483-X

The isoquinolinium bromide (4), on treatment with base, underwent cyclization to give the chiral oxazolotetrahydroisoquinoline (5) with a high diastereoselectivity, which was converted to optically pure salsolidine.

Full text of DOI:10.1016/S0040-4039(00)88483-X

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