Heterocycles p. 1183 - 1192 (2010)
Update date:2022-08-02
Topics: Synthesis Antimicrobial activity Spectral characterization
Subba Reddy
Satheesh Krishna
Koteswara Rao
Naga Raju
A series of novel 5-[(substituted) methyl]-5-oxo-1,3,2λ4, 5λ5-dioxa selenaphosphinan-2-ones (4-17) were successfully synthesized from tris(bromomethyl)phosphine oxide (1) and sodium selenite (2) to form the intermediate(3) which on further treatment with various alcohols/thiols/phenols/aminoacid esters afforded the title compounds (4-17) and their structures were established by multinuclear NMR (1H-, 13C-and31P-) and mass spectral data. Their antimicrobial activity was evaluated and they exhibited promising antibacterial activity. The Japan Institute of Heterocyclic Chemistry.
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(2010)Doi:10.1039/b900787c
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(2011)Doi:10.1021/ol101105v
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(1989)Doi:10.1055/s-0029-1218697
(2010)