High Stereoselectivity in the 1,2-Nucleophilic Additions to a Hindered 2-Alkylidenecyclohexanone: An Example of Predominant Axial Attack by Sterically Demanding Nucleophiles

Article abstract of DOI:10.1021/jo00283a003

1,2-Additions of various nucleophiles including sterically demanding carbanions have been shown to take place preferentially from an axial direction to a highly hindered 2-alkylidenecyclohexanone, thus providing an interesting example where the continuous