Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents

DOI: 10.1021/jm00093a007

Source and publish data:

Journal of Medicinal Chemistry p. 2761 - 2768 (1992)

Update date:2022-09-26

Topics:

Authors:

Warner Warner

Barker Barker

Jackman Jackman

Burrows Burrows

Roberts Roberts

Bishop Bishop

O'Connor

Hughes Hughes

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00093a007

Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol

Full text of DOI:10.1021/jm00093a007

Products guided by the article

Product name:N-[4-[N-(2-amino-4-chloroquinolin-6-ylmethyl)-N-(prop-2-ynyl)amino]-2-fluorobenzoyl]-L-glutamic acid

Cas No:123636-77-1

R&D Labs maybe for 123636-77-1

Jinan Great Chemical Co.,Ltd.

Contact:+86-531-58668191 58668193 58668196 58661173

Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
Hangzhou Mole's Science & Technology Co.,Ltd.(expird)

Contact:+86-571-56880228

Address:15F Guodu development Building, NO.182 Zhaohui Road
ENERGYCO LTD.

Contact:+86-25-83719363

Address:106-7 Chunnan Rd, Chunxi Town, Gaochun, Nanjing, China
Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】

website:http://www.chemboss.com.cn

Contact:+86-531-58591595

Address:No2.Hualong Road, Jinan, China
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.

Relevant to this article

Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: Versatile and switchable access to functionalized proteins

Doi:10.1021/ja800800p
(2008)
Phosphorus-containing derivatives of L-aspartic and L-glutamic acids

Doi:10.1007/s11172-010-0054-y
(2010)
Novel anti-viability ceramide analogs: Design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)- 3-hydroxy-N-tetradecylpropanamides

Doi:10.1016/j.bmc.2010.05.044
(2010)
Metal salt mediated radical reactions of 2-substituted-1, 4-naphthoquinones

Doi:10.1002/ejoc.201000272
(2010)
Iridium-catalyzed asymmetric hydrogenation of β-ketophosphonates with chiral ferrocenyl P,N,N-ligands

Doi:10.1002/aoc.6283
(2021)
Synthesis of functionalized resorcinols by rhodium-catalyzed [5+1] cycloaddition reaction of 3-acyloxy-1,4-enynes with CO

Doi:10.1039/c0cc00747a
(2010)

Article Doi