Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents

DOI: 10.1021/jm00093a007

Source and publish data:

Journal of Medicinal Chemistry p. 2761 - 2768 (1992)

Update date:2022-09-26

Topics:

Authors:

Warner Warner

Barker Barker

Jackman Jackman

Burrows Burrows

Roberts Roberts

Bishop Bishop

O'Connor

Hughes Hughes

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Article abstract of DOI:10.1021/jm00093a007

Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol

Full text of DOI:10.1021/jm00093a007

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Product name:N-[4-[N-(2-amino-4-chloroquinolin-6-ylmethyl)-N-(prop-2-ynyl)amino]-2-fluorobenzoyl]-L-glutamic acid

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