Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents

DOI: 10.1021/jm00093a007

Source and publish data:

Journal of Medicinal Chemistry p. 2761 - 2768 (1992)

Update date:2022-09-26

Topics:

Authors:

Warner Warner

Barker Barker

Jackman Jackman

Burrows Burrows

Roberts Roberts

Bishop Bishop

O'Connor

Hughes Hughes

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00093a007

Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol

Full text of DOI:10.1021/jm00093a007

Products guided by the article

Product name:N-[4-[N-(2-amino-4-chloroquinolin-6-ylmethyl)-N-(prop-2-ynyl)amino]-2-fluorobenzoyl]-L-glutamic acid

Cas No:123636-77-1

R&D Labs maybe for 123636-77-1

Shanghai PotentPharm Science and Technology Co.,Ltd

Contact:86-021-51969655

Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
Lyrin Industrial Corporation Limited

Contact:86-731-82571800

Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Mashilabs(shanghai)Co.,ltd

Contact:+86-21-54391580

Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Henan Sinotech Import&Export Corporation

website:http://www.hasinotech.com

Contact:86-371-86181678

Address:No. 260, Dongming Road,Jinshui District
Beijing Mesochem Technology Co.,LTD

website:http://www.mesochem.com

Contact:0086-10-57862036

Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China

Relevant to this article

Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: Versatile and switchable access to functionalized proteins

Doi:10.1021/ja800800p
(2008)
Phosphorus-containing derivatives of L-aspartic and L-glutamic acids

Doi:10.1007/s11172-010-0054-y
(2010)
Novel anti-viability ceramide analogs: Design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)- 3-hydroxy-N-tetradecylpropanamides

Doi:10.1016/j.bmc.2010.05.044
(2010)
Metal salt mediated radical reactions of 2-substituted-1, 4-naphthoquinones

Doi:10.1002/ejoc.201000272
(2010)
Iridium-catalyzed asymmetric hydrogenation of β-ketophosphonates with chiral ferrocenyl P,N,N-ligands

Doi:10.1002/aoc.6283
(2021)
Synthesis of functionalized resorcinols by rhodium-catalyzed [5+1] cycloaddition reaction of 3-acyloxy-1,4-enynes with CO

Doi:10.1039/c0cc00747a
(2010)

Article Doi