European Journal of Medicinal Chemistry p. 523 - 532 (1988)
Update date:2022-09-26
Topics:
Baggaley, Keith H.
Fears, Robin
Ferres, Harry
Geen, Graham R.
Hatton, Ian K.
et al.
A series of N-substituted amino acid derivatives was synthesized and the compounds were evaluated for their effects on serum total cholesterol, HDL cholesterol and triglycerides in experimental animals.Hyperalphalipoproteinaemic activity was found for some of these compounds tested, especially BRL 26314 (2) and related 3-aryl-2-<(arylmethyl)>aminopropionic acids.Structure-activity relationships are discussed.Keywords: N-substituted amino acid derivatives / hyperalphalipoproteinaemic activity
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