Total synthesis and antimicrobial activity of a natural cycloheptapeptide of marine origin

Article abstract of DOI:10.3390/md8082384

The present study deals with the first total synthesis of the proline-rich cyclopolypeptide stylisin 2 via a solution phase technique by coupling of the Boc-L-Pro-L-Ile-L-Pro-OH tripeptide unit with the L-Phe-L-Pro-L-Pro-L-Tyr-OMe tetrapeptide unit, follo