3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 6. Trans-6-[2-(substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

DOI: 10.1021/jm00164a047

Source and publish data:

Journal of Medicinal Chemistry p. 758 - 765 (1990)

Update date:2022-09-26

Topics:

Authors:

Prugh Prugh

Alberts Alberts

Deana Deana

Gilfillian

Huff Huff

Smith Smith

Wiggins Wiggins

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Article abstract of DOI:10.1021/jm00164a047

A variety of trans-6-[2-(substituted-1-naphthyl)ethyl(or ethyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones were prepared and, upon conversion to their 3,5-dihydroxy carboxylates, were found to have good inhibitory activity against the enzyme 3-hydroxy-

Full text of DOI:10.1021/jm00164a047

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