Tetrahedron Letters p. 4371 - 4374 (2010)
Update date:2022-08-05
Topics:
Müller, Ivonne A.
Kratz, Felix
Jung, Manfred
Warnecke, André
A number of novel acid-sensitive Schiff bases derived from p-aminobenzyl alcohol and various benzaldehyde derivatives were synthesized and were subsequently shown to trigger benzyl elimination reactions. The kinetics of acid-catalyzed hydrolysis at pH 5.0 as well as stability at pH 7.4 were studied using fluorogenic model compounds. Two fluoro-substituted Schiff bases showed efficient hydrolysis at pH 5.0 combined with a long-term stability at pH 7.4 and are considered suitable candidates for the development of anticancer prodrugs.
View MoreSHIJIAZHUANG CHENSHI IMPORT AND EXPORT CO.,LTD
Contact:+86-311-89871056
Address:RM2017 BUILDING CTIANSHAN GALAXY PLAZA,NO168 CHANGJIANG ROAD,GAOXIN DISTRICT,SHIJIAZHUANG CITY, HEBEI,CHINA
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Contact:+36(21)2523420
Address:Head office: 1102 Budapest, SZENT LASZLO TER 24/B. 1/1., HUNGARY / CHINA
Zhejiang Linhai Xinhua Chemicals Factory
Contact:0086-13661858911
Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
website:http://www.shydtec.com
Contact:86-21-57721279
Address:Science and Technology Park, Songjiang District, Shanghai, China
Doi:10.1002/asia.201100097
(2011)Doi:10.1021/jo100877j
(2010)Doi:10.1016/j.jfluchem.2005.11.013
(2006)Doi:10.1021/jm960070+
(1996)Doi:10.1007/BF00978441
(1989)Doi:10.1016/S1386-1425(02)00004-5
(2002)