Bioorganic and Medicinal Chemistry Letters p. 2819 - 2824 (1997)
Update date:2022-08-04
Topics:
Maynard, George D.
Bratton, Larry D.
Kane, John M.
Burkholder, Timothy P.
Santiago, Braulio
Stewart, Kenneth T.
Kudlacz, Elizabeth M.
Shatzer, Scott A.
Knippenberg, Robert W.
Farrell, Amy M.
Logan, Deborah E.
A series of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity has been prepared. Factors affecting receptor binding affinities and oral activity in this series are described
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