Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity

DOI: 10.1016/S0960-894X(97)10097-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2819 - 2824 (1997)

Update date:2022-08-04

Topics:

Authors:

Maynard, George D.

Bratton, Larry D.

Kane, John M.

Burkholder, Timothy P.

Santiago, Braulio

Stewart, Kenneth T.

Kudlacz, Elizabeth M.

Shatzer, Scott A.

Knippenberg, Robert W.

Farrell, Amy M.

Logan, Deborah E.

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Article abstract of DOI:10.1016/S0960-894X(97)10097-X

A series of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H₁/tachykinin NK₁ receptor antagonist activity has been prepared. Factors affecting receptor binding affinities and oral activity in this series are described

Full text of DOI:10.1016/S0960-894X(97)10097-X

Products guided by the article

Product name:Methanone, [1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl-

Cas No:124443-70-5

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