Tetrahedron Letters p. 9403 - 9406 (1996)
Update date:2022-08-04
Topics:
Michael, Joseph P.
De Koning, Charles B.
Stanbury, Trevor V.
A simple synthesis of tricyclic analogues of the quinolone antibiotics bearing a diverse range of substituents on the aromatic ring is described. The key steps involve unprecedented Reformatsky reaction between diethyl bromomalonate and N-arylpyrrolidine-2-thiones 8, followed by cyclisation of the resulting enaminone intermediates 9 in polyphosphoric acid.
View MoreContact:410-273-7300; 800-221-3953
Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA
Tianjin Te-An Chemtech Co., Ltd.(expird)
Contact:+86-22-65378638
Address:A5-8, No.80 Haiyun Street, TEDA
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
WENZHOU M&C FOREIGN TRADE CO.,LTD.
Contact:+86-577-88862917
Address:No.8 Liming West Road,Wenzhou,zhejiang,China
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
website:http://www.shydtec.com
Contact:86-21-57721279
Address:Science and Technology Park, Songjiang District, Shanghai, China
Doi:10.1021/jo00292a041
(1990)Doi:10.1002/chem.201000401
(2010)Doi:10.1021/acs.orglett.1c02256
(2021)Doi:10.1016/j.tet.2010.06.072
(2010)Doi:10.1039/c2dt31667f
(2013)Doi:10.1055/s-0032-1317345
(2012)