Tetrahedron Letters p. 9403 - 9406 (1996)
Update date:2022-08-04
Topics:
Michael, Joseph P.
De Koning, Charles B.
Stanbury, Trevor V.
A simple synthesis of tricyclic analogues of the quinolone antibiotics bearing a diverse range of substituents on the aromatic ring is described. The key steps involve unprecedented Reformatsky reaction between diethyl bromomalonate and N-arylpyrrolidine-2-thiones 8, followed by cyclisation of the resulting enaminone intermediates 9 in polyphosphoric acid.
View MoreJinTan Pingsheng Chemical Co.,Ltd
Contact:+86-519-82828200
Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Compro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Tangshan Moneide Trading Co., Ltd.
Contact:+86-315-8309571
Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Contact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
Doi:10.1021/jo00292a041
(1990)Doi:10.1002/chem.201000401
(2010)Doi:10.1021/acs.orglett.1c02256
(2021)Doi:10.1016/j.tet.2010.06.072
(2010)Doi:10.1039/c2dt31667f
(2013)Doi:10.1055/s-0032-1317345
(2012)
