
Tetrahedron Letters p. 1833 - 1836 (1986)
Update date:2022-08-04
Topics:
Morizawa, Yoshitomi
Yasuda, Arata
Uchida, Keiichi
The reaction of enolate prepared from ethyl 3-methyl-4,4,4-trifluorobutyrate with MoO5-Py-HMPA complex provides ethyl (2S*,3S*)-2-hydroxy-3-methyl-4,4,4-trifluorobutyrate predominantly.In contrast, NaBH4 reduction of the corresponding 2-oxobutyrate affords (2R*,3S*)-hydroxyester preferentially.
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