Synthesis of oxo-phosphoranylidene aminobenzoic acid derivatives by a multicomponent reaction

Article abstract of DOI:10.1080/10426500903258790

2-Aminobenzoic acids or 4-aminobenzoic acid react with dimethyl acetylenedicarboxylate/triphenylphosphine in less than 20 min at 15-25C to produce new organic phosphorus compounds in good to excellent yields. The conversion occurs with selective N- over O-alkylation of the amino group and isolation of the products is accomplished simply by filtration. Copyright Taylor & Francis Group, LLC.