Design, synthesis and biological evaluation of l-dopa amide derivatives as potential prodrugs for the treatment of Parkinson's disease

DOI: 10.1016/j.ejmech.2010.05.062

Source and publish data:

European Journal of Medicinal Chemistry p. 4035 - 4042 (2010)

Update date:2022-08-05

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Authors:

Zhou, Tao

Hider, Robert C.

Jenner, Peter

Campbell, Bruce

Hobbs, Christopher J.

Rose, Sarah

Jairaj, Mark

Tayarani-Binazir, Kayhan A.

Syme, Alexander

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Article abstract of DOI:10.1016/j.ejmech.2010.05.062

A range of amide derivatives of l-dopa were synthesized and investigated for their pharmacological activity and their ability to be converted to l-dopa using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat, as an experimental model of Parkinson's

Full text of DOI:10.1016/j.ejmech.2010.05.062

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