Synlett p. 2009 - 2013 (2010)
Update date:2022-07-31
Topics:
Ceylan, Sascha
Klande, Tobias
Vogt, Carla
Friese, Carsten
Kirschning, Andreas
Inductively heated copper wire inside a flow microreactor can serve as a source for a catalytic copper species that promotes 1,3-dipolar cycloadditions of alkynes with in situ formed azides to yield 1,2,3-triazoles. The same setup was used to carry out decarboxylations of 2-alkynoic acids and for the intramolecular C-O coupling of 2'-bromobiphenyl-2-carboxylic acid. Georg Thieme Verlag Stuttgart.
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