
Tetrahedron p. 5283 - 5292 (1989)
Update date:2022-07-31
Topics:
Paterson, Ian
Gardner, Mark
Banks, Bernard J.
Pd(0)-catalysed coupling between various furyl zinc or tin compounds and vinyl iodides is demonstrated to be a versatile method for the synthesis of 2,3-dialkyl-5-alkenylfurans like 3, as a potential precursors of the ring system of lophotoxin and pukalide.A possible cyclisation substrate was succesfully prepared by glycol cleavage, 21 --> 24, when alcohol oxidation failed.
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(1990)