Synthesis of a new family of 2-ethylidene-γ-unsaturated δ-amino esters via microwave activated Stille coupling

Article abstract of DOI:10.1007/s00726-009-0392-y

A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-δ-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to 1-substituted butenoates of defined geometry.