SYNTHESIS OF 1,3,4-THIAZOLE DERIVATIVES BY THE REACTION OF THIOBENZHYDRAZIDE WITH SOME ACYLACETYLENES

Article abstract of DOI:10.1007/BF00482510

2-Acylmethyl-5-phenyl- and 3-acylvinyl-2-acylmethyl-5-phenyl-1,3,4-thiadiazol-4-ines were obtained by the reaction of terminal α-acetylenic ketones with thiobenzhydrazide.Substituted acetylenic ketones react with thiobenzhydrazide in alcohol to give N,S-b