Synthesis of fully-substituted alkenylimidazoles from N-(cyanoalkyl)amides via the In-mediated allylation of nitrile and dehydrative cyclization cascade

DOI: 10.1016/j.tetlet.2010.09.016

Source and publish data:

Tetrahedron Letters p. 5922 - 5926 (2010)

Update date:2022-09-26

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Authors:

Kim, Yu Mi

Lee, Sangku

Kim, Sung Hwan

Kim, Ko Hoon

Kim, Jae Nyoung

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Article abstract of DOI:10.1016/j.tetlet.2010.09.016

The reaction of allylindium reagents and N-(cyanoalkyl)amides afforded fully-substituted 4-alkenylimidazoles in moderate yields via the In-mediated Barbier-type allylation of nitrile and the following dehydrative cyclization cascade.

Full text of DOI:10.1016/j.tetlet.2010.09.016

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