STUDIES ON THE SYNTHESIS OF NUCLEOTIDYL-PEPTIDE. I: A FACILE SYNTHESIS INVOLVING SELECTIVE P-S BOND CLEAVAGE

DOI: 10.1016/S0040-4039(01)93727-X

Source and publish data:

Tetrahedron Letters p. 2117 - 2120 (1989)

Update date:2022-07-30

Topics:

Authors:

Hotoda, Hitoshi

Ueno, Yoshihito

Sekine, Mitsuo

Hata, Tsujiaki

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Article abstract of DOI:10.1016/S0040-4039(01)93727-X

A dinucleotide dipeptide (H-Ala-Tyr-(pUpU)-OH) was synthesized via a phosphorothioate triester intermediate (1).It was found that the P-S bond was selectively cleaved by the use of (n-Bu3Sn)2O without undesired dephosphorylation of tyrosine.

Full text of DOI:10.1016/S0040-4039(01)93727-X

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