Molecular iodine mediated one step synthesis of 3-substituted-6-(6- substituted-2-oxochromen-3-yl)-7H[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

Article abstract of DOI:10.3184/030823410X12715064952719

Iodine mediated condensation of 3-acetyl-6-substitutedcoumarin (1) with 3-alkyl/aryl-4-amino-5-mercapto[1,2,4]triazoles (2) have been found to give 3-alkyl/aryl-6-(6-substituted-2-oxochromen-3-yl)-7H[1,2,4]triazolo[3,4-b][1,3,4] thiadiazines (3a-n) directly in one step. The reaction has also been carried out using microwave irradiation. This protocol is an improvement on reported methods as it occurs in a single step and avoids the use of highly lachrymatory molecular bromine.