Synthesis and biological evaluation of radio-iodinated benzimidazoles as SPECT imaging agents for NR2B subtype of NMDA receptor

DOI: 10.1016/j.bmc.2010.08.053

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Bioorganic and Medicinal Chemistry p. 7497 - 7506 (2010)

Update date:2022-08-05

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Authors:

Fuchigami, Takeshi

Yamaguchi, Hiroshi

Ogawa, Mikako

Biao, Le

Nakayama, Morio

Haratake, Mamoru

Magata, Yasuhiro

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Article abstract of DOI:10.1016/j.bmc.2010.08.053

In this study, the benzimidazole derivatives were synthesized and evaluated as imaging agents for the NR2B subtype of NMDA receptor. Among these ligands, 2-{[4-(4-iodobenzyl)piperidin-1-yl]methyl}benzimidazol-5-ol (8) and N-{2-[4-(4-iodobenzyl)-piperidin-

Full text of DOI:10.1016/j.bmc.2010.08.053

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