Antitumor Agents. 111. New 4-Hydroxylated and 4-Halogenated Anilino Derivatives of 4'-Demethylepipodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

DOI: 10.1021/jm00167a013

Source and publish data:

Journal of Medicinal Chemistry p. 1364 - 1368 (1990)

Update date:2022-08-06

Topics:

Authors:

Lee, Kuo-Hsiung

Beers, Scott A.

Mori, Masami

Wang, Zhe-Qing

Kuo, Yao-Haur

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00167a013

A series of C-4 hydroxylated and halogenated anilino derivatives of epipodophyllotoxin or 4'-demethylepipodophyllotoxin have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity

Full text of DOI:10.1021/jm00167a013

Products guided by the article

Product name:4'-demethyl-4α-(4-hydroxyanilino)-4-desoxypodophyllotoxin

Cas No:125830-33-3

R&D Labs maybe for 125830-33-3

Chengdu Baishixing Science and Technology Industry Co., Ltd.

website:http://www.cd-bsx.com

Contact:+86-28-88531548

Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
QINGDAO ON-BILLION INDUSTRAIL CO.,LTD

website:http://www.obn.com.cn

Contact:+86-15005320811 +86-532-80681989

Address:F35 Parkson Mansion No.44-60 Zhongshan Rd.
Zipont chem(wuhan）Tech co.，Ltd

Contact:+86-27-87587198

Address:wuhan
Shanghai Hanhong Scientific Co.,Ltd.

website:http://www.chemvia.com

Contact:+86-21-64541543,54280654,13918533501

Address:Jiachuan Road 245
Hangzhou utanpharma Co., Ltd

Contact:86-571-87758773

Address:Room604 ,6F, Block A1-3 Xixi Plaza,No. 588 Wenyi West RD, Hangzhou,310012, China

Relevant to this article

Modification of biologically active amides and amines with fluorine-containing heterocycles 4. Trifluoromethyl-containing heterocyclic pyracetam derivatives

Doi:10.1007/s11172-010-0176-2
(2010)
Isoselenocyanates derived from amino acid esters: An expedient synthesis and application to the assembly of selenoureidopeptidomimetics, unsymmetrical Selenoureas and selenohydantoins

Doi:10.1002/psc.1276
(2010)
Recyclization of 2-iminocoumarin-3-carbonitriles with 2-aminothiobenzamide: A new synthetic route to substituted 2-(2-iminocoumarin-3-yl)quinazoline-4(3H)- thiones

Doi:10.1080/17415993.2010.509506
(2010)
Sigmatropic isomerizations in azaallyl systems: XXI. Alkanimidoylphosphonates and their prototropic and phosphorotropic isomers

Doi:10.1007/s11176-005-0110-8
(2004)
Mn(III)-based oxidative cyclization of N-aryl-3-oxobutanamides. facile synthesis and transformation of substituted oxindoles

Doi:10.3987/COM-14-S(K)57
(2015)
Substituted diketopyrrolopyrroles as input energy units in soluble donor-acceptor dyads

Doi:10.1002/chem.201001953
(2010)

Article Doi