Antitumor Agents. 111. New 4-Hydroxylated and 4-Halogenated Anilino Derivatives of 4'-Demethylepipodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

DOI: 10.1021/jm00167a013

Source and publish data:

Journal of Medicinal Chemistry p. 1364 - 1368 (1990)

Update date:2022-08-06

Topics:

Authors:

Lee, Kuo-Hsiung

Beers, Scott A.

Mori, Masami

Wang, Zhe-Qing

Kuo, Yao-Haur

et al. et al.

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Article abstract of DOI:10.1021/jm00167a013

A series of C-4 hydroxylated and halogenated anilino derivatives of epipodophyllotoxin or 4'-demethylepipodophyllotoxin have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity

Full text of DOI:10.1021/jm00167a013

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