Chinese Chemical Letters p. 939 - 942 (2010)
Update date:2022-09-26
Topics:
Zhang, Shu Lan
Zhai, Xin
Zhang, Shi Jiao
Yu, Hong Hao
Gong, Ping
A series of quinoline-3-carbonitrile derivatives were designed and synthesized. Their cytotoxicity in vitro against four cancer cell lines (A549, HT-29, MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line. Among them, compounds 7c, 7e, 11b, 11f and 11g were more active than Gefitinb against SMMC-7721 cell line.
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Doi:10.1055/s-0030-1258206
(2010)Doi:10.1016/j.molcata.2010.09.006
(2010)Doi:10.1039/c0cc02781b
(2010)Doi:10.1021/jo102060j
(2011)Doi:10.1021/ol1027267
(2011)Doi:10.1002/anie.201004593
(2010)