Journal of Medicinal Chemistry p. 1003 - 1020 (2016)
Update date:2022-08-15
Topics:
Demont, Emmanuel H.
Bailey, James M.
Bit, Rino A.
Brown, Jack A.
Campbell, Colin A.
Deeks, Nigel
Dowell, Simon J.
Eldred, Colin
Gaskin, Pam
Gray, James R. J.
Haynes, Andrea
Hirst, David J.
Holmes, Duncan S.
Kumar, Umesh
Morse, Mary A.
Osborne, Greg J.
Renaux, Jessica F.
Seal, Gail A. L.
Smethurst, Chris A.
Taylor, Simon
Watson, Robert
Willis, Robert
Witherington, Jason
FTY720 is the first oral small molecule approved for the treatment of people suffering from relapsing-remitting multiple sclerosis. It is a potent agonist of the S1P1 receptor, but its lack of selectivity against the S1P3 receptor ha
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