Design, synthesis and preliminary evaluation of some novel [1,4]diazepino [5,6-b]pyrrolizine and 6-(2-oxopyrrolidino)-1Hpyrrolizine derivatives as anticonvulsant agents

Article abstract of DOI:10.1007/s00044-010-9429-8

New series of diazepino[5,6-b]pyrrolizines 7a- c and 8a-c and 6-(2-oxopyrrolidino)-1H-pyrrolizines 10a- c were synthesized through acylation of the key aminonitrile derivatives 5a-c (Scheme 1) with the appropriate acid chlorides. Subsequent cyclization re