Synthesis of novel α-CF3-trifluoroalanine derivatives containing N-(diethoxyphosphoryl)difluoroacetyl group

Article abstract of DOI:10.1016/j.jfluchem.2010.09.010

An efficient synthesis of biologically interesting α-CF ₃-trifluoroalanine derivatives bearing N-(diethoxyphosphoryl) difluoroacetyl moiety in good yields has been elaborated. The key substrate, α-TFM-imino ester, prepared from methyl trifluoro