Pyrazolobenzotriazinone derivatives as COX inhibitors: Synthesis, biological activity, and molecular-modeling studies

DOI: 10.1002/ardp.200900317

Source and publish data:

Archiv der Pharmazie p. 631 - 638 (2010)

Update date:2022-08-04

Topics: Synthesis Biological Activity

Authors:

Raffa, Demetrio

Migliara, Onofrio

Maggio, Benedetta

Plescia, Fabiana

Cascioferro, Stella

Cusimano, Maria Grazia

Tringali, Giuseppe

Cannizzaro, Carla

Plescia, Fulvio

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Article abstract of DOI:10.1002/ardp.200900317

Pyrazolylbenzotriazinones are endowed with a structural analogy with the COX-2 selective inhibitor celecoxib. Considering that our research group has long been interested in the 3-pyrazolyl-substituted benzotriazinones as anti-inflammatory agents, six new

Full text of DOI:10.1002/ardp.200900317

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