Selective Sugar Binding with a Synthetic Polyhydroxy Macrocycle. A Remarkable Selectivity for Fructose over Glucose

Article abstract of DOI:10.1246/cl.1989.1905

D-Fructose, a ketohexose, is readily solubilized in CCl4 via complex formation with resorcinol-dodecanal cyclotetramer (1), in marked contrast to D-glucose, a closely related aldohexose, which shows almost no affinity to 1.The affinity of fructose can be further enhanced by oligomeric modification of 1.