Synthesis and Biological Evaluation of 2-Styrylquinazolin-4(3H)-ones, a New Class of Antimitotic Anticancer Agents Which Inhibit Tubulin Polymerization

DOI: 10.1021/jm00168a029

Source and publish data:

Journal of Medicinal Chemistry p. 1721 - 1728 (1990)

Update date:2022-08-04

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Authors:

Jiang, J. B.

Hesson, D. P.

Dusak, B. A.

Dexter, D. L.

Kang, G. J.

Hamel, E.

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Article abstract of DOI:10.1021/jm00168a029

A novel series of 2-styrylquinazolin-4(3H)-ones which inhibited tubulin polymerization and the growth of L1210 murine leukemia cells was discovered.Extensive structure-activity relationship studies suggest that the entire quinazolinone structure was requi

Full text of DOI:10.1021/jm00168a029

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