Chalcones: A new class of antimitotic agents

DOI: 10.1021/jm00169a021

Source and publish data:

Journal of Medicinal Chemistry p. 1948 - 1954 (1990)

Update date:2022-07-29

Topics:

Authors:

Edwards Edwards

Stemerick

Sunkara Sunkara

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00169a021

A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-propen- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa

Full text of DOI:10.1021/jm00169a021

Products guided by the article

Product name:(E)-3-(3-Dimethylamino-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone

Cas No:127034-03-1

R&D Labs maybe for 127034-03-1

Shanggao Ruiya Fine Chemicals Co., Ltd

Contact:+86-795-2592103

Address:Xingguang Nanlu,Shanggao County Industry Park
Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Chengdu NoVi Biotechnology Co., Ltd.(expird)

Contact:13551243286/028-81458053

Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Du-Hope International Group

website:http://www.np-chem.com

Contact:0086-25-52346877

Address:199, Jian Ye Road, Nanjing, China
Hefei TNJ chemical industry co.,ltd

website:https://www.tnjchem.com

Contact:+86-551-65418695

Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China

Relevant to this article

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Doi:10.2147/DDDT.S166051
(2018)
A global and local desymmetrization approach to the synthesis of steroidal alkaloids: Stereocontrolled total synthesis of paspaline

Doi:10.1021/jacs.5b02631
(2015)
Designer nanorings with functional cavities from self-assembling β-Sheet peptides

Doi:10.1002/asia.201000428
(2011)
Single-Handed Helical Poly(quinoxaline-2,3-diyl)s Bearing Achiral 4-Aminopyrid-3-yl Pendants as Highly Enantioselective, Reusable Chiral Nucleophilic Organocatalysts in the Steglich Reaction

Doi:10.1021/jacs.6b12349
(2017)
HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: Synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice

Doi:10.3390/md11020350
(2013)
Stereoselective synthesis and characterization of (Z)-(-)-4-(1′- Alkoxyl-1′-alkyloxycarbonyl-methylidene)-5(R)-[(1R)-menthyloxy] - Butyrolactones

Doi:10.1080/00397911003611760
(2011)

Article Doi