Chalcones: A new class of antimitotic agents

DOI: 10.1021/jm00169a021

Source and publish data:

Journal of Medicinal Chemistry p. 1948 - 1954 (1990)

Update date:2022-07-29

Topics:

Authors:

Edwards Edwards

Stemerick

Sunkara Sunkara

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Article abstract of DOI:10.1021/jm00169a021

A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-propen- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa

Full text of DOI:10.1021/jm00169a021

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