Stereoselective Δ4-Pipecolic Acid Synthesis via Alkylation of a Vinyl N-Boc-iminium Ion Derived from Baikiain

Article abstract of DOI:10.1016/S0040-4039(00)76188-0

Stereoselective functionalization of Boc-(+/-)-Baikiain was demonstrated via seleno- and iodolactonization to afford lactones 5.These were converted to enecarbamate 7, which undergoes regio- and stereoselective alkylation at C-6 upon treatment with organo