REGIOSELECTIVE SYNTHESIS OF RING A POLYMETHYLATED STEROIDS IN THE ANDROSTANE SERIES

Article abstract of DOI:10.1016/S0040-4020(01)89518-1

Properly protected derivatives 14 and 20 of the common precursor 17β-hydroxy-1-methyl-5α-androst-1-en-3-one (13) have been transformed in a regioselective manner into highly methylated androsta-1,4-diene-3,17-dione derivatives 6-8.Access to the manifold o