Synthesis of aminocyclitols and trihydroxylated indolizidinone from a D-mannitol-derived common building block

Article abstract of DOI:10.1002/ejoc.201001171

The synthesis of 4-amino-4-deoxy-muco-quercitol (22), 4-amino-4-deoxy-(-)- vibo-quercitol (27) and also a trihydroxylated indolizidinone 38 from D-mannitol is described using ring-closing metathesis and diastereoselective dihydroxylation as the key steps.