Monatshefte fur Chemie p. 1095 - 1100 (1989)
Update date:2022-08-02
Topics:
Kappe, Oliver C.
Kappe, Thomas
The synthesis of some 5-cyano-4-hydroxy-2-pyridone derivatives (3a-c) by condensation of 3-aminocrotononitrile (1) with substituted diethylmalonates (2a-c) is described.Reaction of 3a with phosphorus oxychloride yields 4,6-dichloro-3-pyridinecarbonitrile (7a), which reacts with various nucleophiles to give substituted 3-pyridinecarbonitriles (8-10). - Keywords. 3-Pyridinecarbonitriles; 4-Hydroxy-6-oxo-1,6-dihydro-3-pyridinecarbonitriles; 4,6-Dichloro-3-pyridinecarbonitrile; 3-Aminocrotononitrile.
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Doi:10.1021/jm00171a008
(1990)Doi:10.1016/j.tet.2011.01.022
(2011)Doi:10.1039/c0ob00985g
(2011)Doi:10.1016/j.bmc.2011.03.027
(2011)Doi:10.1002/chem.201002964
(2011)Doi:10.1002/hlca.19890720810
(1989)
