Synthesis of Substituted 3-Pyridinecarbonitriles with Potential Biological Activity

Article abstract of DOI:10.1007/BF00809291

The synthesis of some 5-cyano-4-hydroxy-2-pyridone derivatives (3a-c) by condensation of 3-aminocrotononitrile (1) with substituted diethylmalonates (2a-c) is described.Reaction of 3a with phosphorus oxychloride yields 4,6-dichloro-3-pyridinecarbonitrile (7a), which reacts with various nucleophiles to give substituted 3-pyridinecarbonitriles (8-10). - Keywords. 3-Pyridinecarbonitriles; 4-Hydroxy-6-oxo-1,6-dihydro-3-pyridinecarbonitriles; 4,6-Dichloro-3-pyridinecarbonitrile; 3-Aminocrotononitrile.