A convenient synthesis of 4-(perfluoroalkyl)pyrimidines and 4-(perfluoroalkyl)tetrahydropyrimidines

Article abstract of DOI:10.1246/bcsj.63.293

Vinyl perfluoroalkyl ketones formed in situ from the reactions of perfluoroalkyllithiums with ethyl acrylate can easily be trapped with thiouronium and amidinium salts to give 4-(perfluoroalkyl)tetrahydropyrimidines in moderate to good yields. Similarly, ethynyl perfluoroalkyl ketones generated in situ can be converted to 4-(perfluoroalkyl)pyrimidines, although the yields are low.