Synthesis, absolute configuration, stereoselectivity, and receptor selectivity of (αR,βS)-α,β-dimethylhistamine, a novel highly potent histamine H3 receptor agonist

Article abstract of DOI:10.1021/jm00101a021

Depending on the selected synthetic pathway, structural variations of the neurotransmitter histamine led to mixtures of α,β-dimethylhistamines as well as to the corresponding pure optical isomers. One of these isomers, namely (αR,βS)-α,β-dimethylhistamine