Asymmetric synthesis of lometrexol ((6R)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid)

DOI: 10.1021/jo00102a031

Source and publish data:

Journal of Organic Chemistry p. 7038 - 7045 (1994)

Update date:2022-08-05

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Authors:

Barnett Barnett

Wilson Wilson

Wendel Wendel

Winningham

Deeter Deeter

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Article abstract of DOI:10.1021/jo00102a031

An enantioselective synthesis of lometrexol (1) which utilizes (5R)-2-piperidone 18 as a key intermediate is described. Lipase-catalyzed enantioselective esterification of 1,3-propanediol derivative 5 provided (R)-(+)-6, the absolute configuration of whic

Full text of DOI:10.1021/jo00102a031

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