Asymmetric synthesis of lometrexol ((6R)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid)

DOI: 10.1021/jo00102a031

Source and publish data:

Journal of Organic Chemistry p. 7038 - 7045 (1994)

Update date:2022-08-05

Topics:

Authors:

Barnett Barnett

Wilson Wilson

Wendel Wendel

Winningham

Deeter Deeter

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00102a031

An enantioselective synthesis of lometrexol (1) which utilizes (5R)-2-piperidone 18 as a key intermediate is described. Lipase-catalyzed enantioselective esterification of 1,3-propanediol derivative 5 provided (R)-(+)-6, the absolute configuration of whic

Full text of DOI:10.1021/jo00102a031

Products guided by the article

Product name:2-<2-(4-Bromophenyl)ethyl>propanedioic acid diethyl ester

Cas No:127633-42-5

R&D Labs maybe for 127633-42-5

SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD

Contact:+86-755-82412922

Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Henan zhongda Biological Engineering Co., Ltd

Contact:86-28-18109029985

Address:shenzhou road,xuedian industrial estate,zhengzhou city,henan province CHN
GLD peptide scientific lnc.

Contact:21-7631221 15884421033

Address:326 Science and technology,Shanghai,China
Chengda Pharmaceuticals Co., Ltd.

Contact:+86-573-84601188

Address:hengshan Road 5# in Jiashan, zhejiang
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)

Contact:86-532-67773200; 15689126900

Address:Qidu town,Linzi district,Zibo city,Shandong province,China

Relevant to this article

Michael Reaction Inspired Atroposelective Construction of Axially Chiral Biaryls

Doi:10.1021/jacs.0c01963
(2020)
Stereospecific synthesis of C-arabinofuranosides and carba-disaccharide analogues of Motif C of cell wall AG complex of Mtb

Doi:10.1016/j.tetlet.2012.09.015
(2012)
Reactions of lithiated P-diphenyl(alkyl)(N-methoxycarbonyl)phosphazenes with Michael acceptors and aldehydes. Synthesis of 1H-1,2-azaphosphinin-6-ones, β-hydroxy(N-methoxycarbonyl)phosphazenes and 5,6-dihydro-1,3,4-oxazaphosphinin-2-ones

Doi:10.1016/S0040-4020(01)00165-X
(2001)
6′-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola

Doi:10.1016/j.bmcl.2018.10.030
(2018)
Palladium-Catalyzed C-N Coupling of Pyrazole Amides with Triazolo- And Imidazopyridine Bromides in Ethanol

Doi:10.1021/acs.oprd.0c00437
(2021)
Liquid crystals based on calix[4]arene Schiff bases

Doi:10.1007/s10847-009-9620-z
(2010)

Article Doi