Journal of Organic Chemistry p. 7038 - 7045 (1994)
Update date:2022-08-05
Topics:
Barnett
Wilson
Wendel
Winningham
Deeter
An enantioselective synthesis of lometrexol (1) which utilizes (5R)-2-piperidone 18 as a key intermediate is described. Lipase-catalyzed enantioselective esterification of 1,3-propanediol derivative 5 provided (R)-(+)-6, the absolute configuration of whic
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