Palladium-Catalyzed C-N Coupling of Pyrazole Amides with Triazolo- And Imidazopyridine Bromides in Ethanol

DOI: 10.1021/acs.oprd.0c00437

Source and publish data:

Organic Process Research and Development p. 457 - 468 (2021)

Update date:2022-08-05

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Authors:

Bliss, Fritz

Fantasia, Serena

Le Coz, Erwann

Püntener, Kurt

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Article abstract of DOI:10.1021/acs.oprd.0c00437

An efficient palladium-catalyzed coupling between a pyrazole amide and a heteroaryl bromide was developed to enable the streamlined synthesis of a lead candidate for schizophrenia treatment. Process robustness and scalability were achieved using ethanol a

Full text of DOI:10.1021/acs.oprd.0c00437

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