Ro 11-2933, a potential drug in the treatment of cancer and malaria: Synthesis and physicochemical properties; potential metabolites

DOI: 10.1016/0223-5234(89)90053-6

Source and publish data:

European Journal of Medicinal Chemistry p. 493 - 496 (1989)

Update date:2022-07-29

Topics:

Authors:

Ramuz Ramuz

Schmutz Schmutz

Huber Huber

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Article abstract of DOI:10.1016/0223-5234(89)90053-6

Ro 11-2933, 4b, a compound with minor cardiovascular activity has been shown to reverse multidrug resistance in cancer cells as well as chloroquine resistance in Plasmodium falciparum. A useful synthesis of the drug is described. Alkylation of dithiane (2) with chloroalkylamine (3) affords 4b as a crystalline compound in a very good yield. The synthesis of its potential metabolites 7 and 11 has also been carried out.

Full text of DOI:10.1016/0223-5234(89)90053-6

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