Bioorganic and Medicinal Chemistry Letters p. 6088 - 6092 (2010)
Update date:2022-08-05
Topics:
Tang, Haifeng
Yan, Yan
Feng, Zhe
De Jesus, Reynalda K.
Yang, Lihu
Levorse, Dorothy A.
Owens, Karen A.
Akiyama, Taro E.
Bergeron, Raynald
Castriota, Gino A.
Doebber, Thomas W.
Ellsworth, Kenneth P.
Lassman, Michael E.
Li, Cai
Wu, Margaret S.
Zhang, Bei B.
Chapman, Kevin T.
Mills, Sander G.
Berger, Joel P.
Pasternak, Alexander
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.
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Doi:10.1002/chem.201002592
(2011)Doi:10.1016/j.bmcl.2010.12.106
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(2011)Doi:10.1080/10426507.2010.499497
(2011)Doi:10.1002/ejic.201001024
(2011)Doi:10.1002/ejic.201001092
(2011)
