Asymmetric direct aldol reaction of cyclohexanone catalyzed by (N′-benzyl-N′-D-prolyl)-trans-4-hydroxy-L-proline hydrazide

Article abstract of DOI:10.1002/cjoc.201190051

A new proline catalyst, namely (N′-benzyl-N′-D-prolyl)-trans-4- hydroxy-L-proline hydrazide, has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes, affording up to 98:2 dr and 98%