Agents for the treatment of overactive detrusor. I. Synthesis and structure-activity relationships of 1,1'-biphenyl derivatives

DOI: 10.1248/cpb.39.2915

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2915 - 2923 (1991)

Update date:2022-08-05

Topics:

Authors:

Take Take

Okumura Okumura

Takimoto

Kato Kato

Ohtsuka Ohtsuka

Shiokawa

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Article abstract of DOI:10.1248/cpb.39.2915

A series of 1,1'-biphenyl-2,6-dicarboxylic acid diesters were synthesized and examined for their inhibitory activity on guinea-pig detrusor muscle contraction at electrical field stimulation in vitro. Among them, 6-isopropyl 2-methyl 3-hydroxy-5-methyl-2'

Full text of DOI:10.1248/cpb.39.2915

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