Enzymatic preparation of an optically active precursor of the CC-1065/duocarmycin pharmacophore

DOI: 10.1246/cl.1997.11

Source and publish data:

Chemistry Letters p. 11 - 12 (1997)

Update date:2022-09-26

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Authors:

Chenevert, Robert

Courchesne, Gabriel

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Article abstract of DOI:10.1246/cl.1997.11

Acetylation of 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol with vinyl acetate in the presence of porcine pancreatic lipase gave the (R)-mono-acetate (ee = 92%). The (S)-mono-acetate was obtained via acetylation of the diol followed by transesterificat

Full text of DOI:10.1246/cl.1997.11

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